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Oct 18 2021;13(1):112

Notwithstanding the robust preclinical data, luteolin is impeded by suboptimal bioavailability attributed to inadequate solubility, swift metabolic degradation, and insufficient stability, thereby necessitating sophisticated delivery methodologies such as nanocarriers, liposomal formulations, polymeric nanoparticles, and phospholipid complexes to augment its absorption and penetration into the central nervous system

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Polymorphic variants of genes involved in choline pathway and the risk of intrauterine fetal death